Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend International Conference on Neurological disorder and Neuroimmunology Montreal, Canada.

Past Conferences Report

Day 1 :

Keynote Forum

Khaled Alkattan

Alfaisal University, Saudi Arabia

Keynote: Role of Surgery in NSCLC

Time : 10:00-10:45

Neuroimmunology 2018 International Conference Keynote Speaker Khaled Alkattan photo
Biography:

Khaled Manae Al-Kattan, Dean College of Medicine, Alfaisal university and Consultant Thoracic Surgery and lung transplant at King Faisal Specialist Hospital & Research Centre. He was a co-founder of both the Saudi thoracic society and Pan Arab Chest Society. He is the Middle East regent for the European Society of Thoracic Surgery. Have extensive research and publication in his field, presented many abstracts in international symposiums. Was invited as an international speaker in many medical events. He is the Chairman of the National Lung Cancer Study Group and the national lung transplant program.

 

Abstract:

Management of lung cancer remains a challenge; recent advances in medicine had little impact on the outcome of lung cancer. Although surgery remains the best treatment modality for early NSCLC, but are results satisfactory? While advanced NSCLC stage is more common, but can surgery play a role. The best surgical approach depends on do I have a diagnosis, Is the Staging accurate, especially T status (3&4) and with N (2&3), M (1a), Is surgical Treatment curative or improve survival, Is the patient fit for the procedure (Assessment). The best management process should consist on the following: Tumor board approach, Better diagnosis, staging, Better patient assessment, Better anesthesia, Better techniques (VATS, Instruments), Better results (Less Morbidity and Mortality) and More Aggressive (Better Adjuvant therapy). To Improve results we need Screening, Sensitive investigation tools, Better staging of tumors. The role of Lymphadenectomy, Postoperative follow up and
metastasectomy is to be determined. Also Surgical techniques (Sleeve and Enblock resections) , Adjuvant therapy should be now part of the outcome based results. All that will help to definition of poor prognostic factors and achieving better results.

Keynote Forum

Mohammed AlAhmari

Prince Sultan Military College of Health Sciences, Saudi Arabia

Keynote: Noninvasive ventilation (NIV) in Acute Respiratory Failure
Neuroimmunology 2018 International Conference Keynote Speaker Mohammed AlAhmari photo
Biography:

Mohammed AlAhmari is a consultant and Assistant Professor of Respiratory Care. He is the Vice Dean of Post-graduate Studies & Scientific Research; Chairman in Respiratory Care department and Institutional Research Board at Prince Sultan College of Health Sciences, Saudi Arabia. He completed his PhD in Respiratory Medicine, UCL, UK. He is a registered Respiratory Therapist (RRT); certified Tobacco Treatment Specialist (CTTS); and fellow of American Association for Respiratory Care (FAARC). In 2008, he was appointed as a Saudi Governor of Respiratory Care at International Council of Respiratory Care. He won research awards from ATS in 2011 and 2012 for his research on “The NIV in OSA and inflammation related to this therapy”. He has Chaired and lectured at many national and international scientific meetings. He serves as an Editorial Board Member in scientific journals.

Abstract:

Noninvasive ventilation (NIV) is the delivery of positive pressure ventilation to the upper airway without the need for invasive artificial airway. NIV has been extensively used in clinical practice in the last two decades. NIV is well recognized therapy in selected patients with acute respiratory failure (ARF) related to exacerbation of chronic obstructive pulmonary disease (COPD), acute cardiogenic pulmonary edema and immuno compromised patients. Several studies have also shown that noninvasive therapy plays a substantial role in reducing the need for endotracheal intubation, hospital stay, morbidity and mortality. Despite the presence of evidence supporting the use of NIV, there are still wide variations in the actual initiation, usage and NIV utilization throughout the world. This presentation will discuss the rationale to treat acute respiratory failure (ARF) with NIV, considering timing of initiation for such therapy. In early stage of un-established ARF, NIV may prevent invasive ventilation while in established ARF, if predictors of success met, this therapy may help to avoid the endotracheal intubation. Role of NIV in different sittings will be discussed with providing up-to date evidence based medicine. This presentation will demonstrate some data for utilization of NIV.

  • Heart and Lung Transplant | Diagnosis of Pulmonary Disorders
Location: Boardroom 350
Speaker

Chair

Mohammed AlAhmari

Prince Sultan Military College of Health Sciences, Saudi Arabia

Session Introduction

Deborah Pierce

Amana Healthcare Long Term Medical and Rehabilitation Hospital, UAE

Title: Early mobilization of the ventilated patient: The when, how, why and impact

Time : 12:10-12:40

Biography:

Deborah Pierce has obtained a Bachelor of Health Science in Physiotherapy from Auckland University of Technology, New Zealand and has recently (2016) attained her Master’s in Business Administration (Health Management) from the University of Tasmania, Australia. She has spent over 8 years in tertiary acute care settings, specializing in Critical Care, Neurorehabilitation and General Medical Rehabilitation. She has joined Amana Healthcare as a Team Leader for Rehabilitation in 2013. She acts as a HAAD Examiner for the physiotherapy profession and is CPHQ certified for her commitment to quality service provision and the progression of rehabilitation in UAE.

Abstract:

Objective: This presentation aims to highlight the evidence based practice regarding early mobilization and implementation of this for greatest efficacy and efficiency across the continuum of care in a developing health system.
 
Content: Effects of immobility, notably for the cardiorespiratory system; Effective and efficient evidence based safe mobilization practices; and impacts for the patient, the healthcare facilities and healthcare system.
 
Conclusion: Conclusions will be drawn regarding the current challenges faced in implementation in practice and recommendations for implementation in a developing health system.

Fadi Hamed

Cleveland Clinic, UAE

Title: Lung transplant in 2016, what is new?
Biography:

Fadi Hamed is a Staff Physician in the Respiratory and Critical Care Institute at Cleveland Clinic, Abu Dhabi. Prior to joining Cleveland Clinic Abu Dhabi, he has worked as an Associate Staff in the Department of Pulmonary and Critical Care Medicine at Cleveland Clinic. He has earned his Medical degree from the University of Jordan in Amman. He completed his residency in Internal Medicine from Albert Einstein Medical Center in Philadelphia, US, where he has also served as a Chief Medical Resident for a year on completion of his Residency training. He completed his Fellowship in Pulmonary and Critical Care Medicine at Cleveland Clinic in Cleveland, Ohio, US.

Abstract:

Since the first human lung transplant in 1963, more than 40,000 lung transplant procedures have been performed worldwide. Although lung transplant is usually the last resort for patients and physicians when medical care has been exhausted, lung transplantation is now an accepted therapy for the management of a wide range of severe lung disorders, with evidence supporting quality of life and survival benefit for lung transplant recipients. Indications include diverse spectrum of pulmonary diseases affecting the airway, parenchyma and vasculature. In 2014, the International Society for Heart and Lung Transplantation (ISHLT) released an updated consensus document for the selection of lung transplant candidates, following 2 previous editions published in 1998 and 2006. This consensus includes indications for referral and listing according to disease and highlights absolute and relative contraindications. Despite all the advances in medical management post lung transplant, acute rejection and infection remain the major complications affecting survival in the first year post lung transplant. On the other hand, chronic lung allograft dysfunction in form of bronchiolitis obliterans syndrome (BOS) or restrictive allograft dysfunction (RAD) remains major cause of morbidity and mortality resulting in graft dysfunction, making 5 years survival of post-transplant patients around 50% in average.

Mouhamad Ghyath Jamil

King Faisal Specialist Hospital& Research Center, Saudi Arabia

Title: Heart rate variability and outcomes prediction in critical illness
Biography:

Mouhamad Ghyath Jamil completed his Graduation at Aleppo University. After completing his Residency in Internal Medicine at University of North Dakota, he joined the university as an Associate Professor. He completed his fellowship in Pulmonary, Critical Care and sleep Medicine at George Washington University. He is Board Certified in Internal medicine, Pulmonary, Critical Care and Sleep medicine. He is currently a Consultant in Pulmonary, Critical Care and Sleep Medicine at King Faisal Hospital and Research Center. He is the Medical Director; Medical ICU and Sleep Medicine Unit. He is an active member of many societies including ACCP, SCCM, ASSM, SCCS, STC, and MCCA. He has a major interest in E-health and Simulation; he established the first Tele-ICU program in Middle East.

Abstract:

Introduction: Heart rate variability (HRV) is an indicator of the dynamic equilibrium between the sympathetic and parasympathetic divisions of the autonomic nervous system. We hypothesized that baseline HRV variables and changes during resuscitation may predict outcomes from critical illness.
 
Methods: A prospective, observational study was performed on inpatients that required a rapid response team (RRT)consultation. 24-hour holter monitoring and serial measurements of physiological and biochemical data were made. Heart rate variability was measured as time domains measured over 24 hours (SDNN, ASDNN, rMSSD, pNN50%, SDANN, mean NN) and frequency domains measured hourly (very low frequency- VLF, low frequency- LF, high frequency- HF, low/high ratio). The research ethics committee approved the study protocol (RAC no. 2151069).
 
Results: 53 patients were enrolled, mean APACHE II score was 23.5±6.3, age 52±24.3 years. Day one SOFA score was 8.9 (range 1, 23). 40 patients (75.5%) required ICU admission; ICU mortality rate was 27.5%. HRV was significantly higher in RRT consultations who stabilized and did not require ICU admission; time domains; ASDNN [33(IQR21) vs. 18(IQR21), p=0.024], rMSDD [23(IQR19) vs. 15(IQR18), p=0.036] and frequency domains; mean VLF [16.6(IQR7.3) vs. 9.3(IQR10), p=0.018],
mean LF [12.4(IQR11) vs. 5.4(IQR7), p=0.009], mean HF [9.3(IQR12) vs. 4.8(IQR7), p=0.011]. Baseline HRV was significantly higher in survivors; ASDNN [31.5(IQR24) vs. 12(IQR9),p=0.002], rMSDD [25(IQR19) vs. 11.5(IQR10), p=0.012], pNN50% [6(IQR9.5) vs. 0.75(IQR2.5), p=0.002], mean NN [732.5(IQR291) vs. 570(IQR87), p=0.006], mean VLF [12.1(IQR11.8) vs. 5.3(IQR4), p=0.002], mean LF [8.5(IQR10.2) vs. 3.4(IQR4.6), p=0.009], mean HF [7.5(IQR6) vs. 3.3(IQR3.9), p=0.005]. Survivors also demonstrated a significantly larger increase in HRV over 24 hours of resuscitation; delta VLF [3(IQR8.1) vs. -0.6(IQR8), p=0.015], delta LF [3.2(IQR5.9) vs. -0.3(IQR7.6), p=0.017].
 
Conclusion: HRV analysis appears to be a powerful identifier of outcomes in critical illness. Baseline values and changes over the first 24 hours of resuscitation accurately predicted both the need for ICU admission and survival

  • Cardiac Diseases |Pulmonary Disorders
Location: Boardroom 350

Chair

Hatem H. AlMasri

King Abdulaziz Medical City, Saudi Arabia

Biography:

Eman Sami Badawod is pursuing her Medical School Graduation at King Abdulaziz University in the year 2016

Abstract:

Introduction: Troponin I (trop-I) is considered the most sensitive cardiac biomarker for diagnosis of acute MI. However, it lacks specificity since it can be elevated with other conditions such as pulmonary embolism and non-coronary cardiac disorders.
 
Aim: The primary objective was to estimate the sensitivity and specificity of trop-I at different level in comparison to the clinical diagnosis. The secondary objectives were to determine any association between trop-I elevation with left ventricular (LV) dysfunction among MI patients and with right ventricular (RV) dysfunction among PE patients.
 
Method: We performed a retrospective chart review of 122 patients admitted to King Abdulaziz Medical City-Western Region with diagnosis of MI or PE between October 2012 and March 2014.
 
Results: Among 122 patients included, 64 were diagnosed to have MI and 58 were diagnosed to have PE. The first trop-I blood level value at presentation was higher with MI than with PE, (p-value=0.03). The maximum blood level value of trop-I was also significantly higher in patients with MI, (p-value<0.001). At trop-I blood level of 0.05, the sensitivity was 98.4% and specificity was 84.5%. At the level of 0.1, the sensitivity was reduced to 76.6% but with almost perfect specificity of 98.3%. There was a strong association between post-PE elevation of trop-I and RV dysfunction (p-value=0.002). 
 
Conclusion: The blood level of trop-I may have clinical implication in differentiating MI from PE at the initial presentation. Trop-I level is not associated with LV dysfunction among MI patients, but has strong association with RV dysfunction among PE patients.

Biography:

Azar Hussain is a Cardiothoracic Surgeon with particular interest in Pulmonary Hypertension and Heart Failure. He recently completed his MSc in Translational Research at University of Bristol and currently, pursuing his MD. He is a HYMS Clinical Research Fellow in Department of Cardiothoracic Surgery at Castle Hill Hospital working with Prof Alyn Morice and Prof Mahmoud Loubani was awarded two prizes at the International Conference on Cardiovascular Medicine held in August 2016. He won the best Young Researchers Forum award and the best Poster Presentation award in recognition of his research on “Pulmonary arteries, constrictors and dilators” that have clinical implications for the treatment of patients with pulmonary hypertension in general but more specifically in patients undergoing complex heart surgery.

Abstract:

Background: Acute pulmonary hypertension following cardiac surgery can have a significant effect on postoperative morbidity and mortality. Phosphodiesterase inhibitors, nitric oxide and prostacyclin analogues are commonly used to treat acute pulmonary hypertension. In recent years our group has used human pulmonary artery rings in an in vitro model to investigate pulmonary vascular resistance. The aim of this study was to characterize the pharmacological effects of clinically used vasodilators on the human pulmonary vasculature in comparison to the endogenous pulmonary vasodilators, atrial natriuretic peptide and brain natriuretic peptide.
 
Methods: 35 pulmonary artery rings of internal diameter 2-4 mm and 2 mm long, mounted in a multi-wire myo-graph system, were used for measuring changes in isometric tension. After preconstruction with PGF2α (11 μM) concentration response curves were constructed to sildenafil (Sd), milrinone (Mi), sodium nitroprusside (SNP), atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), epoprostenol (Ep) and iloprost (Ip) by cumulative addition to the myo-graph chambers. 
 
Results: Sd, Mi, SNP, ANP, BNP, Ep and Ip caused concentration-dependent vasodilation in the pulmonary arteries (EC50 1.06 μM, 1.01 μM, 22.6 nM, 1.11 nM, 28.78 nM, 29.40 nM and 1.43 nM respectively). The order of efficacy was ANP=Ep=Ip=Mi > SNP > Sd > BNP and the order of potency was ANP>Ip>SNP>BNP=Ep>Mi=Sd.
 
Conclusion: This is the first study to demonstrate the differential in vitro effects of clinically used pulmonary vasodilators and endogenous vasodilators on small human pulmonary vessels. ANP was the most potent and effective vasodilator whereas BNP had little effect. The prostacyclin analogues and milrinone had similar efficacy to ANP in small human pulmonary arteries. BNP could be acting as a partial agonist in small human PAs and in subsequent studies BNP was found to inhibit relaxation to ANP, which could have significant implications in decompensated heart failure.

Biography:

Zeinab Norouzi has recently completed her Graduation in Medicine at Lorestan University of Medical Sciences, Iran. Her interests include “Diabetes mellitus, internal medicine and cardiology”. She is writing two books: One is about diabetes mellitus with focus on Patient Education. The other is about Cardiology for Medical Students. Both of them will be published in Persian in 2017.

Abstract:

Cardiac tamponade happens when the collection of fluid in pericardial space is more quickly than the expansion of the pericardial sac to incorporate the excess fluid. It can cause a high pressure in pericardial sac and prevents the effective heart contraction. In acute tamponade, a small amount of fluid can cause problem and even death for the patient, but in chronic tamponade, the pericardial sac can stretch to hold more than even 1000 mL, without significant symptoms in patient. This form of tamponade happens in tuberculosis pericarditis. We report a patient with chronic tamponade due to tuberculosis
pericarditis. A 13 year old female, presented to the clinic with hematuria, dysuria, fatigue and peripheral edema. She was completely comfortable and the vital signs were stable. A computerized tomography (CT) scan of abdomen and pelvis was ordered that revealed moderate ascites, right-sided pleural effusion, and massive pericardial effusion. She was admitted to the hospital. The positive signs in complete physical exam was rising of JVP, decreased the respiratory sounds in right hemithorax,paradoxical pulse and 1+ edema in the lower limbs. Also, the heart sounds were muffled. The initial ECG showed tachycardia and low voltage of QRS complex. Echocardiographic findings were 3.6 cm pericardial effusion and the collapse of right ventricle in diastole. Pericardio synthesis and pericardial window were recommended and 2500 mL of bloody fluid was drained. Pericardial effusion analysis showed lymphocyte dominancy and a high level of ADA (80 U/L). The work up for TB was negative. According to the symptoms, pericardial and pleural effusion and high level of ADA and living in endemic area for TB, empiric therapy was initiated and the response of the patient was excellent without any complications in two months follow up.

Mutlaq AlSubaie

King Fahad Specialist Hospital, Saudi Arabia

Title: A case of shrinkage lung syndrome as a first presentation of SLE
Biography:

Mutlaq medical Intern was born in Dammam on April, 6th 1992. Member in Saudi Diabetes And Endocrine Association (SDEA) Since 2015. Member in Sanad Children’s Cancer Support Association Since 2014. has participated and organized several events and campaigns as the annual pre-conference public education activity “Neurosurgery public Awareness Campaign” , “Save a Life” section at the annual Scitech Emergency Medicine Exhibit, 7th and 8th medical career day. Currently work on several researches as cardiovascular response to aerobic exercises in children with type one diabetes mellitus and functional barriers experienced by patients after long- term clubfoot surgery.

Abstract:

Shrinking lung syndrome (SLS) is a rare manifestation of the respiratory system associated with autoimmune diseases, and it is characterized by reduction in the lung volume, elevation of the diaphragm, restrictive pattern on pulmonary function test (PFT) with no parenchymal involvement. The pathogenesis of SLS remains unknown, a number of hypotheses suggested a diaphragmatic weakness due to phrenic nerve neuropathy, pain induced diaphragmatic inhibition and dysfunction of the diaphragm due to steroid therapy. Systemic steroids are considered as a first line treatment, immunosuppressive agents can be used. Rituximab showed successful improvement after a failure of systemic steroid therapy.SLS is even rarer as a first presentation of a connective tissue disease. Our patient referred from a local hospital to investigate an unresolved pneumonia, the patient had a positive history of joint pain and photosensitive skin rash mainly in her face, and after the lab work a diagnosis of SLE and SLS has been made.